Great article, great advice, except for this bit:

"You should wonder at the things nobody else is wondering about. If everybody’s wondering about apples, go wonder about oranges."

I think this is terrible advice. If your heart is in apples, stick with apples, switching to oranges just because nobody else is doing it goes against everything else he says in the article. Originality-for-its-own-sake never produced good art, just self-conscious, pretentious rubbish.