Yes, nruddock has a point. A wrist doesn't twist on it's own. The forearm twists, but not the wrist joint itself. Check the file menu at (and since I don't have it open, atm - I'm guessing. I think it's under figure) Figure/Limits or Set Limits. If that's checked, there will be certain things that you can't do with a joint like a bend or a twist that can't be done to the real joint :). If you still want to twist the hand anyway, uncheck the Limits.

Laurie