short answer - yes you can.

If you have the Advanced version of DS3 or 4, you can use Uber Environment2 to make lighting more realistic  and the Human Surface Shader to adjust the surface settings.

Good lighting should include not just  full illumination lights but  also just specular (to make the highlights pop).

 

As for shadow depends on how sharp you need the shadows to be. Raytraced shadows are created in real time as the render progresses, which means that a render can take MUCH longer if you have many raytraced lights. They are far more accurate BUT, even at the softest setting, are still quite sharp. Mapped shadows are softer but are precalculated and created before the render starts. Sometimes a combination of 1 raytraced 1 shadowmapped can yield the desired result.