Since you're not posting an image of the pose, I have to guess. Mostly the dynamics go wrong when there is no room for it. If your clothe has sleeves and the arms are moved close to the body, the mesh may overlap. The simulation desperately tries the fabric to a point where it's no longer inside of the mesh, which usually leads to massive distortions.

Make sure that there is enough room for the simulation. If you don't think that this helps, I would suggest you post an image of the pose so that we can see what's happening.

A ship in port is safe; but that is not what ships are built for.
Sail out to sea and do new things.
-"Amazing Grace" Hopper

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