Good one! I had a Cajun friend several years ago who enjoyed the "game of insults."

His favorite was "Eric, is that your face-or did your neck throw up?" He had dozens of these-he also had a distinctive accent-and unique mannerisms- my response was to develop a spot on imitation of him-and feed it back to him. He surrendered!

Quote - Yo mama so ugly when she was born, the midwife slapped her mama.  :)