According to the producer, MD will be able to create quad meshes in one of the next updates. No idea if this will make it more usable in a whole, but if you plan to create conformers it may prevent the need for a retopo. Doing a retopo in Silo surely is possible in a reasonable time with the topo brush or the surface tool, but still it's a lot of work.

In my experience, triangled meshes behave better in the cloth room than quad meshes. The MD clothes aren't really slower to sim if the number of polys is comparable. But if you want to have good looking cloth, a high poly count is a must and that will cost a lot of time in the simulation. Your milage may vary, though.

A ship in port is safe; but that is not what ships are built for.
Sail out to sea and do new things.
-"Amazing Grace" Hopper

Avatar image of me done by Chidori.