ETA: I don't believe that the Perfect Series and V4WM are necessarily mutually exclusive. Perhaps they can be used together. I've never tried.

I can happily confirm that The Perfect Series and V4WM are not mutually exclusive and have been using the two together for many months adding the new ones as they are released.  I have had no real problems and even if there is poke through is small and easily rectified.  Often there is no poke through so long as the clothes have gone through Outfitter first.  The other benefit is that a number of the Perfect Series allows you to adjust the level of the effect, something very useful with some poses. 

 

 

I use Poser 13 on Windows 11 - For Scene set up I use a Geekcom A5 -  Ryzen 9 5900HX, with 64 gig ram and 3 TB  storage, mini PC with final rendering done on normal sized desktop using an AMD Ryzen Threadipper 1950X CPU, Corsair Hydro H100i CPU cooler, 3XS EVGA GTX 1080i SC with 11g Ram, 4 X 16gig Corsair DDR4 Ram and a Corsair RM 100 PSU .   The desktop is in a remote location with rendering done via Queue Manager which gives me a clearer desktop and quieter computer room.