I have installed all my programs on the 'C' drive but then I took an image of the drive which has a back up stored in two different locations.  

My Poser runtimes are external and backed up every week, using Karen's Replicator, which means in theory, I can install a couple of new drives copy the image and the runtimes overnight and have the system back where it was with minimal hassle.   I did the same on a non-Poser PC at the end of last year and it worked as planned so it should work.

 

 

I use Poser 13 on Windows 11 - For Scene set up I use a Geekcom A5 -  Ryzen 9 5900HX, with 64 gig ram and 3 TB  storage, mini PC with final rendering done on normal sized desktop using an AMD Ryzen Threadipper 1950X CPU, Corsair Hydro H100i CPU cooler, 3XS EVGA GTX 1080i SC with 11g Ram, 4 X 16gig Corsair DDR4 Ram and a Corsair RM 100 PSU .   The desktop is in a remote location with rendering done via Queue Manager which gives me a clearer desktop and quieter computer room.