If you have your workflow designed a specific way, the new install will detect it and in the first splash dialogue you can choose to import those settings. Otherwise, there is no significant difference in how Blender looks and acts, except that if your graphics card supports it, you now have access to a new internal render engine Cycles and also BMesh.

I suggest you get on to BlenderArtists.org and have a wee sticky-beak there about these new features. I personally love them. Some don't. But they are now a part of Blender (more BMesh than Cycles) so it's a force to contend with. If that doesn't float your boat, you can always stay with a version that works for you.

Monterey/Mint21.x/Win10 - Blender3.x - PP11.3(cm) - Musescore3.6.2

Wir sind gewohnt, daß die Menschen verhöhnen was sie nicht verstehen
[it is clear that humans have contempt for that which they do not understand] 

Metaphor of Chooks