You might see strange behavior as bloating or badly morphed appearance.  Scenefixer or EZSkin2 will attempt to detect transparency, bump, displacement maps by their connections to the PoserSurface and automatically change their gamma's to 1.  However, MAT Room complicated shader node structures might prevent the script from successfully detecting the target nodes and initiating any gamma change at all.  I most cases, through my observations, the scripts have been very, very reliable and accurate.