PP2012 can become unresponsive if you have Multi-threaded Bending turned on. As I have a quad core machine, I only noticed it when loading a Genesis figure via DSON, but, as a general rule of thumb it's best to turn it off.

It's also worth uninstalling it and reinstalling it when a service release comes out. Last night, I uninstalled and reinstalled PP2012 and then only installed SR3.1 and it all runs a lot more smoothly. Stuff getting overwritten time after time probably messes things up so a clean install is likely to be better.

CHEERS!