OK, you just gave us the missing piece of the puzzle.

What follows are my clearly labeled opinions and experiences. Others may offer other advice.

Issue #1: Most conforming clothing was not modelled to look "right" with generously endowed women. Especially if you have used add-ons to enhance the curves. To reference an old joke, the endowed girls have curves in places where most girls don't even have places!

An effect that I often see trying to use conforming clothing with a large breasted model is that the top folds under the breasts rather than "tenting" over them. 

If this is the effect you are seeing, I have an answer for you, although you won't like it.

Dynamic clothing.

I ran into this trying to get a bra to fit one of my ladies who could not find a conformer up to the job. Here's how to do it.

1. Go to frame 30 and pose your character as you wish. Mark this as a key frame.

2. Go to frame 1 and zero all body morphs.

3. Load the DYNAMIC (NOT conforming... they are different!) clothing item. MAKE SURE THERE IS NO POKETHRU!

4. Go to the cloth room and clothify the dynamic item.

5. Set it to collide with the shoulders, chest and abdomen.

6. Run the simulation.

Result: Clothing that fits a girl with lots of assets.

If you don't "get" this, feel free to siteemail me. I'll be happy to help you.