> Quote - can you suggest a little more specifically where I am wrong in the flow of the face topology    It would be helpful thanks

 

Sure. Have a look at the area highlighted. I think you've brought the cheek too close to the mouth, not allowing for the folds and skin movement that happen in various expressions and through age. If you compare that area of your mesh to a face built for animation, you'll see there's a very big difference in the way you're handling that section and my concern is that it will trip you up when it comes time for expressions or if you ever do an old version of her.