Yep, it's all in the indexing, basically, go to every AppData folder (you have to have 'access hidden files and folders' checked) you can find and run a search (top right box) if it asks if you want to index it, do it. It sped everything up, not just Poser. I used to wonder why Windows Live Mail was always slow at checking emails, it was the caches, they weren't indexed.

Now every folder I know of that has caches is indexed, it's like having a new computer again!

CHEERS!