Quote - Some good points and excellent examples. My contribution - V4, Poser render and finished image (cropped from original). Hopefully she's got a bit of character ...

Would have been good if the OP had come back to clarify whether they meant realistic faces or just taking V4 away from that default look. Quite different things - Jessica Rabbit is a character!

wimvdb - love that render - is that V4 in Octane?

Yes, it was a quick setup and render (the body was still in the zero position). I added the morph and added an expression. In the plugin I changed the skin to my SSS version, then changed the eyes texture to get one without burnt-in reflection, changed the eyesurface transparency a bit to allow more light on the eye. I used an HDR as lightsource and rendered. Render took about 10 minutes to get at this quality.