Aside from a lot of wasted screen space on both sides of the page when viewing on a widescreen monitior, a minor problem is that when my cursor hovers over an item it no longer automatically opens drop-down menus like it use to do before the change, but now it require a mouse click to do the same thing.  Like I said, a minor nit to pick.

Intel Core I7 3090K 4.5 GhZ (overclocked) 12-meg cache CPU, 32 Gig DDR3 memory, GeoForce GTX680 2gig 256 Bit PCI Express 3.0 graphic card, 3 Western Difgital 7200 rpm 1 Tb SATA Hard Drives