Do you mean this?

http://arstechnica.com/gadgets/2012/05/new-74-android-mini-computer-is-slightly-larger-than-a-thumb-drive/

Your post is confusing because the title says Thumb Drive, and the body says Thumb Computer. Two different creatures, so which is it?

A thumb drive is another term for a flash drive - it's a small USB device that acts as an external/portable hard drive, about the size of your thumb (hence the name). You just plug it in, copy files to it, and go. 

The tech is similar to SSD drives (solid state drives), or the storage on your phone or iPod. You can run small programs from it. Trying to run a program as large as Poser probably would not be a good idea tho. Never tried it. Maybe someone here has. I'd say its not recommended, but that's just my opinion.

A thumbdrive computer tho is something else. 

 

~Shane