I think the problem is the runtime folder you are using is in one of the Program Files folders.  Do not put user data there, these are protected folders ever since Vista.  Since you are using both Studio and Poser it would be best to create a new shared runtime library.  The recommended location is either the User Documents or Public Documents folders.  I don't like loading up the Desktop as SickenlySweete suggested.  If you have a separate data drive or partition that would the best location.