In my opinion to achieve a closeup photo realistic look renders you need an extreme high resolution skin texture and as I know there are not so many in Poser characters only few vendors make photo realistic skin textures one of them is Danae like the metropolitan collection London character and maybe some other vendors make high resolution skin textures. The second issue is you have to use more light and shadows in your renders like the hand holding the parfum bottle there are no shadows, if you put some more shadows by applying some lights the hands will look as if she is holding the bottle, at present render you have done her hands looks like in the air and far away from the bottle, the blue ring on her finger has no shadows as well. As nothing is perfect in this world if you have some photoshop skills you can make some minor retouches by using the Liquify tool in photoshop to correct the uneven fingers position. In my renders using several light with shadows are must as well as photoshop corrections. In my opinion a poser render will never look photo realistic unless you use special lights, for me the most difficult part in poser renders are to play with lights, you have to experiment a lot of time with lights and I am sure you can get it as you like if you spend more time. Good luck!!!!!!