For a simple plane like glass, you could do this fairly easily with a script.  (And it's been done, by me and by PhilC.)

You have to build a customized OBJ first with new vertices and facets shaped to match the appropriate shatter pattern, then animate the movement of the pieces.  

The problem comes with more complex things like a brick or steel or wood frame building.  Bricks would have to be modelled separately, and you'd have to account for the rebar in the concrete, or the studs or beams in a frame structure.   Way too specific for a script to handle.

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