"V4 has such a high polycount zBrush is about the only app that works for me personaly.
V5 has a much lower polycount so I could use C4D with her."

Yeah, even the whole V4 mesh can be manipulated pretty smoothly in my archaic version of Zb... Take that mesh into wings and it's lag city. The things I do in wings are more like sliding edges or tightening and nudging small sections of vertices, things at a really micro level usually on isolated exported body parts like the head for instance. I've never encountered any offset difficulties or scaling issues with wings, it's a straight export from Poser as morph target with groups_morph in wings_import into poser with all setting unchecked_apply morph target process.

I've never tried making morphs in Carrara, I've been using it to make plant primitives, lathed polyline objects and scattered grouped objects (like C4D's arrays I guess) occasionally. Being that Poser content runs natively in there I suppose I should look more closely as it has displacement and poly painting tools but I've found making selections somewhat difficult, things can get out of whack quickly... Inexperience.