Just to add my experience into the mix.  I use an SSD for my 'C' drive with Windows and Poser loaded onto that, other programs are installed onto a conventional hard drive.  My reasonsing behind this is the PC was built for Poser and it gets used everyday.  All temp folders for Windows, Web browsers and the like are remapped to a standard drive.  This gives me a fast launch of Windows and Poser, not essential, but I notice the difference when waiting for my old, non SSD rig to launch.  I have a second SSD, but this is an M drive version sat on the motherboard and is used to accelerate a standard hard drive holding my Poser content.

 

The system runs every day and at least four days a week (I work part time) it runs from dawn to dusk, often rendering while I use it for other things or, on long renders, while I get on with real life.  The system has been used in this way for about eighteen months without problems from either of the drives.

 

 

 

I use Poser 13 on Windows 11 - For Scene set up I use a Geekcom A5 -  Ryzen 9 5900HX, with 64 gig ram and 3 TB  storage, mini PC with final rendering done on normal sized desktop using an AMD Ryzen Threadipper 1950X CPU, Corsair Hydro H100i CPU cooler, 3XS EVGA GTX 1080i SC with 11g Ram, 4 X 16gig Corsair DDR4 Ram and a Corsair RM 100 PSU .   The desktop is in a remote location with rendering done via Queue Manager which gives me a clearer desktop and quieter computer room.