ZBrush's Dynamesh feature is very similar in some respects to the way Sculptris works. The interface of ZBrush can be intimidating but really, you don't spend as much time screwing with it as you may think. Most of your time is spent with your brush and your object (ZBrush calls objects subtools).  You can watch some of the creation of this guy - which started from spheres - right here:

 

http://youtu.be/3KaJDh0qzfc

and here:

http://youtu.be/86uZqu3KOuo

 

And this one is another Dynamesh model. Here you can see the entire workspace and how quickly I was able to get from start to finish using ZBrush's Dynamesh feature (there's a timer running as I work). Dynamesh is great for speed sculpting.

 

http://youtu.be/PPyS5C-aMf0