I'm not sure I agree.  I never install in Program Files but I don't have Poser on the c: drive either.  I think the first target would be the main drive and possibly common locations.  I survived before UAC and I'm fine now. :)

I use an AV and Malware protection and run my browser with NoScript/ABP and am very selective about what I let through.  My network is set up so that only machines with specific MAC addresses can come aboard.  I run daily backups.

I'm not dead against UAC, that's for each person to decide for themselves.  On Win 8, truly halting UAC requires setting that up in the policy editor and that also disables Metro Apps, so it comes with a price.  I could care less about Metro Apps, the Lucky Charms Bar, Sky-dippy doo drive and all of that so I could care less :D

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