Even a relatively low poly mesh will drape fairly well in a cloth sim. 

One option that doesn't seem to get explored often is to use the cloth room to create the morph targets for jcms, elbow bends, shirt bends... this could go a ways to add some realism. 

When running the sims you'd have to think smart in terms of what polygons to constrain and which to keep default, so as not to distort the overall clothing item too much.

@Daz3d
@ShareCG