With DS your content can go anywhere you want it to go, in my case that's a 500Gb external drive, the only content still on C drive is the stuff that came with my P6 & Debut, and the built-in content that comes with the DS installer, that normally ends up in Appdata which is a hidden directory.

There are only a handful of file types that DS uses that you can't edit, the main one being the old .DAZ scene file, it holds the pathway to the DSO, DSD & DSV files required to rebuild the scene, so move or lose any of these data folder files and your scene is screwed, it also holds the pathway to any textures used. The .DSE and some DS1 & 2 .DSB files are in an encrypted binary format and can't be edited, regular .DSB files are in a binary format, they require the IDE script editor which is now part of DS4, everything else is in an ascii format. What catches most is that DUF & DSF files are compressed, so opening them in a text editor is a bit like opening a .CRZ or .PPZ in one, all you see is garbage, DS has a handy batch convert tab that will allow you to uncompress any DUF & DSF file.

On my F drive I have a folder called "Runtimes", I have 5 DS content directories in there, 1 for my DS3 and earlier stuff, one for my DS4 stuff, a combined (Poser & DS) directory for Dawn, a WIP folder for stuff I'm fixing/making, and a My Library folder which is where Genesis & G2F/G2M are stored. I also have a dozen Poser runtimes in there, V4 has her own runtime as does M4, V3 & A3, I have scenery runtimes, vehicle runtimes.
So you can keep Genesis (and G2) separate from the rest of your content quite easilly.