Here is an example however there are some heavy use of photoshop :D And its actually really hard, and doesnt look exactly as i wanted.

But anyway i think you would really have to think outside the box with special textures for the characters and objects you use, so you could get as close to a final product in poser as possible before taking it into photoshop or gimp for finishing up. Also set up special lights for poser which would give these comic style shadows, which you have done quite nicely in the last render i think.