A couple of thinsgs I am going to add. 

1. Poser Companion Files (PoserCF) are Python Scripts. Poser prefers that Python Scripts are in the main/base Poser Runtime. For speed purposes, I personally recommending installing them there. 

2. Whenever possible make the Library Pane external. 

3, If your genesis files are no longer in the same directory path as your PoserCF files, make sure the runtime that is in the Content Directory with your Genesis/G2F/G2M files are in is mapped to the Poser Library. 

4. It greatly speeds things up if you are not using an external drive, and is even better if your cache folder is on an SSD. 

 

Even without an SSD, Genesis (with most of the available morphs installed), after the first load, loads on my machine, significantly faster than V4 plus injecting Morphs++. In fact it loads faster than Roxie, without morphs with an SSD, in Poser. YMMV.

Also note if things are bogging down, turn off Sub-D in the DSON Importer until you are ready to render. (Set it to -1 or in the dropdown.)