I use two monitors and multiple windows.  My startup file opens them all but I hate having to close them all separately.  I've just found a small tool that deals with this; see thread for 'bxmouse' tool.

I like to use my main monitor (on the right) for just the stage and put pallets or windows on the left one.  In Premiere Pro I have the timeline spread across the bottom of both monitors.  In Photoshop I have pretty much every pallet open so I don't have to search for the things.