Clearing out the PMD file (or rather recreating it properly) seems to resolve the problem of the PMD+.pz2 not working when run a second time.

I needed to start from a genuine V4 Blank CR2. Found brief easy-to-follow video instructions from DarkEdgeDesign here BlankCR2.mp4 http://www.youtube.com/watch?v=MBYugBlmVQw - basically load your figure into Poser, turn off IK, zero rotations (Joint Editor), save figure as 'XYZ Blank', open the CR2 in Morph Manager, delete all morphs, resave over 'XYZ Blank.cr2', edit the CR2 to remove the 'inkychain' sections and resave over 'XYZ Blank.cr2'. That's it.

Then use Nerd3D's instructions to create the PMD file and the PMD+/PMD-.pz2 files.

The procedure (at least for a single independent morph) seems to be so simple that there's no point in pondering which is better. In the time it would take to come to a decision you can create both the INJ/REM.pz2 and PMD+/PMD-.pz2 versions and let the user decide.

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The 3Dcheapskate* occasionally posts sensible stuff. Usually by accident.
And it usually uses Poser 11, with units set to inches. Except when it's using Poser 6 or PP2014, or when its units are set to PNU.

*also available in ShareCG, DAZ, and HiveWire3D flavours (the DeviantArt and CGBytes flavour have been discontinued).