There are so many directions to go in...I think anything with organ harvesting, disease-cure testing, etc. will keep things somewhat current in terms of what a lot of more contemporary sf/f readers are looking for.  And it doesn't have to be limited to organ harvesting, you could go the Frank Herbert route and with some female criminals (for high crimes at least) they could function as...well...birth machines.  It's a bit grim and I suspect that is something that could open a whole 'nother pandora's box.