DS4 can be used without Genesis or Genesis 2. There are several advantages in using it with Gen4 or even Gen3 figures. Plugins need to be updated but the dynamic cloth one is included and so are others that were add-ons with DS3.

All in all I strongly advice to make the transition.

Cheers.

Paolo

https://www.preta3d.com
FB: https://www.facebook.com/RealityPlugIn
Tw: @preta3d
G+: https://plus.google.com/106625816153304163119
The Reality Gallery: https://reality-plug-in.deviantart.com