I have PoserPro 2012 AND IE 11 and have not had any problems....yet. I do use the external library tho (Air) which might be why I'm not having a problem. I seem to remember it was the embedded library that was causing all the grief. Try what everyone says, especially moriador's suggestion....do NOT install the content runtimes that you use to the program folder (the Poser folder inside Program Files or Program Files (x86)). If you use any OS after Vista you'll have a problem with Poser and UAC if you do. Your content runtimes should be outside of these folders, like in the Documents folder.

Laurie