Of course. You even can make skin textures from scatch, using noise and marble patterns and appropriate color mixtures and some free merchant resources for eyes and lips and paint a bit yourself plus a few contrasts filters and whatever comes along. So it won't hurt to use the low res image for a start as well, blur it a bit, and so on.

Please add some bump/displacement maps and appropriate specular maps as well, and perhaps even maps that control SSS.

have fun 

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Usually I'm wrong. But to be effective and efficient, I don't need to be correct or accurate.

visit www.aRtBeeWeb.nl (works) or Missing Manuals (tutorials & reviews) - both need an update though