I have been using a Mac and Poser since the original version. It works fine.

If you plan on doing content creation, there are a few things that you miss but you can also run those on a emulated partition if you really need them. Most times you would be able to get by without them.

One thing to know is regarding merging runtime folders. It can be a bit tricky on older versions of the OS because it replaces rather than merges. But you can get around that and it shouldn't be a problem with a new Mac.

Again, most issues would be only if you wanted to make content but if you just want to use stuff, 97% of stuff will work OK. This is true at Rendo, RDNA, DAZ, etc.