I was just able to get a dress for v4 to work on v6. I did get some odd points for some constrained verts but those were fixed with the smoothing brush.

Is poser crashing or is the simulation failing?

If the simulation is failing, the big thing to check is poke through. Also, if you're using conforming clothing converted to dynamic, those don't always work, try something made to be dynamic and if you can find it for your g2 figure.

If poser is crashing, it maybe the scene is too much for your computer. Genesis seems to take up a lot of resources. Try a very low poly dress (do you have any of Judy's?) and some very simple, sparse hair.

If this doesn't help, hopefully someone else with know more.

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