My DS library is in the default location, on a different drive to my Poser runtimes. If I can be bothered importing a figure using DSON I save it to a different (Genesis) runtime for Poser. Seems to work fine.

You can also create Poser CF files inside Studio for any content that doesn't come with one. At least in theory you can... I've seen how to do it, but haven't had a need to try it yet.