So Genesis 2 just loads default on tippy toes now?

The file looks like some kind of morph to be used with high heels from a bobbie25 set. When Genesis 2 loads have your tried resetting the figure to default pose and shape. If it continues to behave oddly you may want to consider reinstalling the Genesis 2/ Female base and see if that helps. Sorry I can't offer more direct help, hope you get it sorted.