I like Andrew's proposal but I think it could be pushed one step further with letting the user assign his own shortcuts, be they to keys or buttons. Then, the user could assign the operations to the keys or buttons  he tends to use the most. Even better, if you change modes, like  going from modeling to rigging or animation, you could reassign the keys and buttons, and Blender would remember them.

It's already possible to assign your own shortcuts and hotkeys in Blender.  You can reassign hotkeys for existing shortcuts, and/or replace them with your own (be careful if you do this, that you don't over-wright something important.  Every action in Blender can be assigned to a hotkey or shortcut, even mode switching can be changed,  The problem is, you need to know all of the existing hotkey combinations, so when you assign something, you aren't replacing something important.  For an example, I have assigned vertex, edge, and face modes to their own hotkeys like I had them in 3dsmax, which makes modelling a lot faster than clicking the UI buttons, or choosing the different modes from a dropdown menu.  If you use the Pie Menu addon, you can customize what modes will appear in the menus there as well.  WHen you change hotkeys, or assign new ones, you just gotta remember to save the Preferences in that session, or the defaults will appear the next time you open the software.

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Tools :  3dsmax 2015, Daz Studio 4.6, PoserPro 2012, Blender v2.74

System: Pentium QuadCore i7, under Win 8, GeForce GTX 780 / 2GB GPU.