Not sure this will help, but here's what I do: I have a V4 (and Dawn, and Antonia) figure all set up with shaders for skin, mouth, eye-colour and transparency, and eyelashes (for both PNG and JPG application - different shaders) in a base folder for them. For each figure, I have the image files in a central folder called AllSkin and the following grouped shaders (the example below is for V4):

-- Shader.Body (this is what all skin will connect to)
-- Skin.Face
-- Skin.Limbs
-- Skin.Torso
-- Skin.Mouth
-- Eyes.Clr
-- Eyes.Surface (the transparent bit)
-- Eyes.Lashes

on a central figure (I call her Katie-CyclesMats.blend) specifically there for that purpose. When I import a scene and a figure (usually I import the posed figure separately), I'll Append the entire node tree for the appropriate figure from that .blend file ... you can multi-select all of the node sets at one go.

Then, I'll set up, say, the nostril for the scene figure, then use the Copy Settings widget to copy to clipboard, then paste from clipboard for each associated material. It's still tedious to do, but it's heaps faster than doing them all by hand.

Happy to share the nodesets, btw...

Monterey/Mint21.x/Win10 - Blender3.x - PP11.3(cm) - Musescore3.6.2

Wir sind gewohnt, daß die Menschen verhöhnen was sie nicht verstehen
[it is clear that humans have contempt for that which they do not understand] 

Metaphor of Chooks