I do agree with one thing ssgbryan bring ups: If all your characters are dial-spins, genesis 1/2 or generation3/4 -- they will look too similar. My hubby knows exactly nothing about Poser or Daz, except that I use it, but when I questioned him about which renders seemed to be using different base figures, he was pretty much on the money with his guesses when the characters were based on commonly used morph packs. The facial morphs are frequently just a tad too subtle, even at full strength.

However, as soon as you start mixing and matching some morphs by vendors who sculpt their own -- Capses, Joe Quick, and Cris Palomino come to mind, among others (Tempesta does some very original work, too as well as the team at RDNA), the appearance of the characters begins to look more and more distinct. Since I figured this out, I've been able to get as much distinct variety as I need with just V4 or genesis. Granted, I'm not illustrating a story with hundreds and hundreds of characters. But in over ten years, I haven't yet put the same character in more than one full sized and print ready render.

When it comes to variety for characters, I find hair to be the most limiting factor (and the lack of convincing facial hair in Poser). But perhaps that's just me. :)

Btw, Joe Quick's morph packs for Generation 4 Daz peeps are now free on ShareCG. I recommend them heartily.

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PoserPro 2014, PS CS5.5 Ext, Nikon D300. Win 8, i7-4770 @ 3.4 GHz, AMD Radeon 8570, 12 GB RAM.