I have no trouble with downloads (and manifests, using the ini file edit) on a different drive. Download location can be set in the DIM preferences, to set the manifests location (they are small files, I move them to keep them safe if I have to reinstall Windows) go to C:UsersYOUAppDataRoamingDAZ 3DInstallManagerUserAccounts and edit the OverrideManifestDir= and optionally (if you download the thumbnails for DIM) the OverrideThumbnailDir= lines in the Account.ini file. Use forward slashes /, not back slashes , as the folder separator. Move your existing manifests/downloads/thumbnails to the new location.