I think a lot depends witch app ya started with. I started in TrueSpace .I had a very difficult time with LW.but C4D felt a lot like TrueSpace so. LW ,Softimage.Blender all feel a lot a like to me.

The first thing that drives me nuts is why they can't put a simple move,zoom,ratate icons in there app's.

but I'll use what ever app has the tools.

I sculpt better in MudBox then zBrushes ,it's just smoother.but zBrush has all the tools thou so.I use both.

I do wish Poser would get a more up to date UI.I always assumed zBrush coders took a lot of acid.Only explanation I can think of for that UI.but I use it just fine.

Allegorithmic ,Blender,Poser all use the nodes n wires .

I can't remember all those node n wire ,hotkeys etc etc.

Blenders free cause they couldn't sell it.Softimage is gone.n LW's not what it once was.

They just never get users want simple,fast UI.

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The Artist that will fight for decades to conquer their media.
Even if you never know their name ,your know their Art.
Dark Sphere Mage Vengeance