When it comes to V4, M4, etc. working in either will produce things that work in both, except for material presets and shaders. It comes down to what you are more comfortable working with.

Having said that, there are quite a few major V4 vendors that use DS to do the work you are describing (No I am not going to drop names.) and have been doing it for some time. Doing the work in DS means you can set up EXP morphs and it is easier to set up clothing for M4's shoulders.