I have just shut my computer down and waited 10 seconds and restarted it, and my Poser 10 still crashes out on start as before.

The message before (by "nerd") directed me to https://support.microsoft.com/en-us/kb/3133431, which directed me to https://www.microsoft.com/security/pc-security/updates.aspx, which is all about WIndows 8 and Windows 7 but says nothing about Windows 10.