No trouble for me and I use mainly G3F. As example, for my current project I have: Genesis3 (Collision), Season dress for G3F (clothe simulation) , Legacie Hair for G3F (hair simulation) and some high resolution props (collide objects). The VWD simu worked well (will post a render soon I hope)

As you, I have 32 gig of mem and never reached the limit . My computer is 3 years old