is possible ......load pic to a plane (add a little emission to pic for a backlight ) an set up smoke sim just in front add a wind/vortex or other force to make pretty swirls and stuff depending (on you and comp) can take 20 mins to a full day !! to get a pic u like

am sure theres free smoke brushes out there and then theres paint programs that help a lot with this type of stuff take about 10 mins

I love blenders sims but they take a lot of setting up ...........then time to run ..........then the tweaks and run again

just saying lol ..........need any help yell out but is lots of tuts on you tube