Did it work on Windows10 before? Did you changfe location of Runtimes? I found win10 less sloppy in access rights than win7 and before were. That is a good thing, but old school organisation like writing into a runtime in the program files folder may not work. Poser itself has solved this but of course older plug-ins can still rely on yesterday's innocence. Try to run Poser as administrator. This is not a good permanent solution but it may help you out on occasions.