It should be fine if you let the Poser installer use its defaults. As for number of threads, Poser will default to the number of cores of your processor(s). So with a simple quad core CPU, Poser will default to 4 render threads. With a HyperThreaded quad core CPU, Poser will default to 8 render threads. If you want to be able to do other things with minimal lag while Poser is rendering, you can lower Poser's priority.

I would generally use separate process. If you have a 32bit machine, separate process is crucial to allow as much memory allotment as possible.

Let the Poser installer place the runtime library in shared documents; do not put your own runtime stuff in program files; User Account Control will block saving files to that runtime.

Poser 12, in feet.  

OSes:  Win7Prox64, Win7Ultx64

Silo Pro 2.5.6 64bit, Vue Infinite 2014.7, Genetica 4.0 Studio, UV Mapper Pro, UV Layout Pro, PhotoImpact X3, GIF Animator 5