I suggest giving Daz Studio a try since it is free. They also provide enough free models/assets to get a good feel for the program. Do a search on the Daz3d website for "toon shaders" and it will give you the results for a few products that can produce 2D style renders. I have the Sketchy toon shader product, and it works good for me. The OSO toon shader also looks interesting, although I have yet to try it. ( Toon/comic renders, especially 2D style, aren't really my thing.)

I can't really help you much regarding Poser. The last time I used it was over 15 years ago, and only for an hour or two.